これまでの軌跡

2009年度

• 11月19日～11月24日、インドのプーネ市のNational Chemical Laboratoryで開催された INSA Platinum Jubilee International Symposiumにて、「高分子ポリフェノール（リグニン 配糖体、加水分解性タンニンの重合体）のユニークな生物作用」について講演：坂上　宏

2010年度

• ９月４日（土）第10回日本臨床中医薬学会学術大会（於：高志会館）シンポジウム２ 「リグニン配糖体の機能：植物分布、抗ウイルス作用、免疫担当細胞に対する作用」 を講演、坂上　宏 11月7日（日）第28回日本歯科東洋医学会学術大会（於：奥羽大学）「代替医療として のリグニン配糖体の機能性」　坂上　宏
  
• 11月19日～11月24日、インドのプーネ市のNational Chemical Laboratoryで開催された INSA Platinum Jubilee International Symposiumにて、「高分子ポリフェノール（リグニン 配糖体、加水分解性タンニンの重合体）のユニークな生物作用」について講演：坂上　宏

これからの日程

2011年度

• ササヘルス講演会：H23年 地区研究会開催日程（会場はこちら）

  • 6/26(日) 名古屋⇒講師：坂上　宏
  • 7/10(日) 札幌 ⇒講師：松田　友彦
  • 7/18(月・祭日)福岡⇒講師：岩本祥子
  • 7/24(日) 広島⇒講師：坂上　宏
  • 8/ 7(日) 東京⇒講師：坂上　宏
  • 9/18(日) 大阪⇒講師：坂上　宏
  • 10/16(日)仙台⇒講師：松田　友彦

出版情報

バックナンバー
総説
Sakagami H: Apoptosis-inducing activity and tumor-specificity of antitumor agents against oral squamous cell carcinoma. Japanese Dental Science Review 46: 173-187, 2010
Sakagami H, Kushida T, Oizumi T, Nakashima H and Makino T: Distribution of lignin carbohydrate complex in plant kingdom and its functionality as alternative medicine. Pharmacology & Therapeutics 128: 91-105, 2010.  

ブック
Sakagami H: Chapter 5.1.8. Oral Cavity Cancer. In: Cancer Report 2010, eds, Tuncer AM, Moore M, Qiao YL, Yoo K-Y, Tajima K, Ozgul N, Gultekin M, 　　　pp222-226, 2010, MN Medical & Nobel Publishing Company, Ankara, Turkey.

発行予定

坂上　宏「代替医療としてのリグニン配糖体の機能性」日本歯科東洋医学会誌第30巻１・２号

ブック
Sakagami H and Watanabe S: Beneficial effects of mulberry on human health in : Phytotherapeutics and Human Health: Pharmacological and Molecular Aspects, Nova Publishers. (in press)

・　歯周病診断マーカーとしてのAP24遺伝子の可能性：治療効果のEBMと健康食品の効力の判定
・　リグニン配糖体の受容体とシグナル伝達経路の同定
・　口腔扁平上皮癌細胞を選択的に傷害する物質の探索
・　骨粗鬆症などの骨系統疾患の予防と治療薬の開発
・　アルツハイマー病などの神経変性疾患の予防と治療薬の開発
・　筋ジストロフィーなどの筋肉変性疾患の治療薬の開発
・　プロテインキナーゼAATYK/LMTKの活性調節と生理的役割の解明

坂上プロジェクト
（１）松かさ

1. 坂上宏：松かさエキス、食品機能素材III、シーエムシー出版、pp224-227, 2005.
2. 坂上　宏：代替医療としての松かさリグニン配糖体の機能性、New Food Industry 48 (8), 23-32, 2006.
3. López BSG, Yamamoto A Utsumi K, Aratsu C and Sakagami H: Clinical pilot study of lignin-ascorbic acid combination treatment of herpes simplex virus. In Vivo 23: 1011-1016, 2009

（２）桑の実ジュース

1. Sakagami H, Asano K, Satoh K, Takahashi K, Terakubo S, Shoji Y, Nakashima H and Nakamura W: Anti-stress activity of mulberry juice in mice. In vivo 20: 499-504, 2006.
2. 坂上宏、小林正樹、古賀紀子、高橋仁美、立川理恵子、田代忠正、長谷川彰彦、佐藤和恵、栗原華絵子、五十嵐武、金本大成、寺久保繁美、中島秀喜、中村渡：代替医療としての桑の実ジュースの機能性New Food Industry 48(11): 31-39, 2006.
3. Sakagami H, Asano K, Satoh K, Takahashi K, Kobayashi M, Koga N, Takahashi H, Tachikawa R, Tashiro T, Hasegawa A, Kurihara K, Ikarashi T, Kanamoto T, Terakubo S, Nakashima H, Watanabe S and Nakamura W: Anti-stress, anti-HIV and vitamin C-synergized radical scavenging activity of mulberry juice fractions. In Vivo 21: 499-506, 2007.
4. 渡邉　悟、星野浩子、篠原尚子、中村　渡、坂上　宏：桑の実ジュースの成分と飲料開発、東京聖栄大学紀要　第３号、13-18, 2011
5. Sakagami H and Watanabe S: Beneficial effects of mulberry on human health In:Phytotherapeutics and Human Health: Pharmacological and Molecular Aspects. Nova Publishers (in press)

（３）マスティック

1. 高橋慶壮、坂上 宏、小林正樹、橋本 研、鈴木史香、五十嵐武、栗原華絵子、中島秀喜、清水貴壽、武田 健、佐藤和恵、渡辺秀司、中村 渡：多機能食品としてのマスティックの生物学的作用、New Food Industry 49 (4), 1-8, 2007.
2. 坂上　宏、周麗、佐藤和恵：マスティックの機能性の追及、New Food Industry 51 (No. 3): 9-20, 2009.
3. Sakagami H, Kishino K, Kobayashi M, Hashimoto K, Shimetani A, Nakamura Y, Takahashi K, Ikarashi T, Fukamachi H, Satoh K, Nakashima H, Shimizu T, Takeda K, Watanabe S and Nakamura W: Selective anti-bacterial and apoptosis modulating activities of mastic. In Vivo 23: 215-224, 2009.

（４）カカオハスク・カカオマス

1. 坂上　宏、前田裕一、大澤謙二：カカオハスクの多様な生物作用と代替医療における機能性、 New Food Industry 50 (4): 1-9, 2008.
2. Sakagami H. Satoh K, Fukamachi H, Ikarashi T, Simizu A, Yano K, Kanamoto T, Terakubo S, Nakashima H, Hasegawa H, Nomura A, Utsumi K, Yamamoto M, Maeda Y and Osawa K: Anti-HIV and vitamin C-synergized radical scavenging activity of cacao husk lignin fractions. In Vivo 22: 327-332, 2008.
3. 坂上　宏、前田裕一、桜井孝治：カカオマスリグニン配糖体の新しい機能性を求めて、 New Food Industry 53: 1-10, 2011.
4. Sakagami H, Kawano M, May Maw Thet, Hashimoto K, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Haishima Y, Maeda Y and Sakurai K: Anti-HIV and immunomodulation activities of cacao mass lignin carbohydrate complex. In Vivo 25: 229-236, 2011  

（５）ササヘルス：クマザサ葉アルカリ抽出液

1. 坂上　宏、渡辺悟、横手よし子、谷口純子、大泉高明：クマザサ抽出液（ササヘルス）の多様な 生物作用と代替医療における機能性、New Food Industry 50 (5), 17-24, 2008
2. Sakagami H, Amano S, Kikuchi H, Nakamura Y, Kuroshita R, Watanabe S, Satoh K, Hasegawa H, Nomura A, Kanamoto T, Terakubo S, Nakashima H, Taniguchi S and Oizumi T: Antiviral, Antibacterial and Vitamin C-synergized Radical Scavenging Activity of Sasa senanensis Rehder extract. In Vivo 22(4): 471-476, 2008.
3. 坂上　宏*、周　麗、儲　慶、王　勤濤、北嶋まどか、大泉　浩史、大泉　高明：クマザサ抽出液 （ササヘルス）の抗炎症作用、New Food Industry 51(No. 1): 27-34, 2009
4. Zhou L, Hashimoto K, Satoh K, Yokote Y, Kitajima M, Oizumi T, Oizumi H and Sakagami H: Effect of Sasa senanensis Rehder extract on NO and PGE2 Production by activated mouse macrophage-like RAW264.7 cells. In vivo 23: 773-778, 2009
5. 坂上　宏、周　麗、河野みち代、メイ・モウ・テツ、長谷川秀夫、田中庄二、町野守、天野滋、 黒下礼奈、渡部茂、金本大成、寺久保繁美、中島秀喜、関根圭輔、白瀧義明、植沢芳広、毛利公則， 儲　慶、王　勤濤、北嶋まどか、大泉　浩史、大泉　高明：　クマザサ抽出液（ササヘルス）の 抗炎症作用に基づく口腔環境改善効果の可能性、New Food Industry 52 (2) 1-10, 2010.
6. Sakagami H, Zhou Li, Kawano M, Thet MM, Takana S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Hao ZC, Uesawa Y, Mohri K, Kitajima M, Oizumi H and Oizumi T: Multiple Biological Complex of Alkaline Extract of the Leaves of Sasa senanensis Rehder. In Vivo 24: 735-744, 2010.  

（６）シイタケ菌糸体培地培養エキス

1. 河野みち代、坂上　宏、佐藤和恵、塩田清二、金本大成、寺久保繁美、中島秀喜、牧野　徹： シイタケ菌糸体培地培養エキス（L･E･M）のリグニン様活性、New Food Industry 51: 1-10, 2009.
2. Kawano M, Sakagami H, Satoh K, Shioda S, Kanamoto T, Terakubo S, Nakashima H and Makino T: Lignin-like activity of Lentinus edodes mycelia extract (L･E･M). In Vivo 24: 543-552, 2010.
3. Kawano M, Thet MM, Makino T, Kushida T and Sakagami H: DNA mircoarray analysis of signaling pathway in macrophages stimulated by lignin-carbohydrate complexes from Lentinus edodes mycelia extract (L･E･M). Anticancer Res 30: 2567-2576, 2010.
4. 坂上　宏、植木淳一、島田亜希、小野真那巳、菅藤歌織、若林英嗣、南部俊之、嶋田　淳、牧　純、 山本正次、北嶋まどか、大泉浩史、大泉高明、牧野　徹：抗酸化剤および植物抽出液の紫外線に 対する細胞保護作用、New Food Industry 53: 11-19, 2011.
5. Kushida T, Makino T, Tomomura M, Tomomura A and Sakagami H: Enhancement of dectin-2 gene expression by lignin-carbohydrate complex from Lendinus edodes extract (LEM) in mouse macrophage-like cell line. Anticancer Res 31: in press, 2011.

（７）その他の植物

1. Motohashi N, Kawase M, Sakagami H and Busia K: The Lutein – Prevention and Treatment for Age-Related Diseases, Chapter 1: Prevention of age-related diseases by lutein and zeaxanthin. “Chem. Pharmaceutical Sciences (CPS)” (“RSFLASH”, India), 1-35, 2006.
2. Watanabe S, Hashimoto K, Tazaki H, Iwamoto Y, Shinohara N, Satoh K and Sakagami H: Radical scavenging activity and inhibition of macrophage NO production by fukinolic acid, a main phenolic constituent in Japanese butterbur (Petasites japonicus). Food Science and Technology Research 13 (4): 366-371, 2007.
3. Motohashi N and Sakagami H: Functionality of Anthocyanins as Alterative Medicine. Top Heterocycl Chem (ed., Noboru Motohash) 15: 1-48, 2008, Springer-Verlag Berlin Heiderberg.
4. Molnar J, Engi H, Gyemant N, Schelz Z, Spengler G, Ocsovszki I, Szucs M, Hohmann J, Szabo M, Tanacs L, Molnar P, Deli J, Krenn L, Kawase M, Wakabayashi H, Kurihara T, Shirataki Y, Sakagami H, Motohashi N and Didiziapetris R: Multidrug resistance reversal of cancer cells by selected carotenoids, flavonoids and anthocyanins. Top Heterocycl Chem (ed., Noboru Motohash) 15: 133-159, 2008, Springer of Germany.
5. Motohashi N and Sakagami H: Anthocyanins as functional food colors. Top Heterocycl Chem (2009)16: 1-40, (ed., Noboru Motohash), Springer-Verlag Berlin Heiderberg.

（８）診断法の確立

1. 長谷川秀夫、坂本光央、野村明子、田中庄二、町野守、辨野義己、坂上宏、安井利一： Porphyromonas gingivalis、Tannerella forsythensis及びTreponema denticolaよりも 病態特異的なAP24の歯周診断指標としての意義、臨床検査53: 381-388, 2009.

（９）口腔癌撲滅プロジェクト

1. Motohashi N, Kawase M, Satoh K and Sakagami H: Cytotoxic potential of phenothiazines. Current Drug Targets Vol 7 (9): 1055-1066, 2006.
2. Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H and Sakagami H: Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines. Anticancer Res 26: 1917-1924, 2006.
3. 坂上　宏：腫瘍選択性の高い物質の探索：アポトーシス誘導活性との相関、日薬理誌127: 322-328, 2006.
4. Kuroda M, Aoshima T, Haraguchi M, Yound MCM, Sakagami H and Mimaki Y: New oleanane glycosides from the roots of Gomphrena macrocephala. Nat Prod Commun 1: 431-439, 2006.
5. Takeuchi R, Hoshijima H, Nagasaka H, Chowdhury SA, Kikuchi H, Kanda Y, Kunii S, Kawase M and Sakagami H: Induction of non-apoptotic cell death by morphinone in human promyelocytic leukemia HL-60 cells. Anticancer Research 26 (5): 3343-3348, 2006.
6. Sasaki M, Okamura M, Ideo A, Shimada J, Suzuki F, Ishihara M, Kikuchi H, Kanda Y, Kunii S and Sakagami H: Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin. Anticancer Res 26: 3373-3380, 2006.
7. Engi H, Sakagami H, Kawase M, Parecha A, Manvar D, Kothari H, Adlakha P, Shah A, Motohashi N, Ocsovszki I and Molnar J: Tumor-specific cytotoxicity and MDR-reversal activity of dihydropyridines. In Vivo 20: 637-644, 2006.
8. Ideo A, Sasaki M, Nakamura C, Mori K, Shimada J, Kanda Y, Kunii S, Kawase M and Sakagami H: Cytotoxic activity of selected trifluoromethyl ketones against oral tumor cells. Anticancer Res 26: 4335-4342, 2006.
9. Kuroda M, Aoshima T, Haraguchi M, Young MCM, Sakagami H and Mimaki Y: Oleanane and taraxerane glycosides from the roots of Gomphrena macrocephala. J Nat Prod 69: 1606-1610, 2006.
10. Higano T, Kuroda M, Sakagami H and Mimaki Y: Convallasaponin A, a new 5b-spirostanol triglycoside from the rhizomes of Convallaria majalis. Chem Pharm Bull 55: 337-339, 2007.
11. Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N and Sakagami H: Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines. Anticancer Res 27: 133-144, 2007.
12. Hatsukari I, Hitosugi N, Ohno R, Hashimoto K, Nakamura S, Satoh K, Nagasaka H, Matsumoto I and Sakagami H: Induction of apoptosis by morphine at clinical concentration against human tumor cell lines in vitro. Anticancer Res 27: 857-864, 2007.
13. Sakagami H, Kobayashi M, Chien C-H, Kanegae H and Kawase M: Selective toxicity and type of cell death induced by various natural and synthetic compounds in oral squamous cell carcinoma. In Vivo 21: 311-320, 2007.
14. 坂上　宏：ホルメシスの概念：薬物の持つ２面性、New Food Industry 49(5):1-6, 2007.
15. Das U, Kawase M, Sakagami H, Ideo A, Shimada J, Molnar J, Molnar J, Barath Z, Bata Z and Dimmick JR: 3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: A novel phamacophore displaying potent multidrug resistance reversal and selective cytotoxicity. Bioorg Med Chem 15: 3373-3380, 2007.
16. Sakagami H, Yamazaki T, Onuki H, Yamazaki A, Hibino Y, Hashimoto K, Kanda Y, Kunii S, Yokote Y, Nakajima H and Shimada J: Rapid changes in amino acid and polyamine metabolism during copper-induced cell death of human gingival fibroblast. In Vivo 21: 835-840, 2007.
17. Kawase M, Tanaka T, Kan H, Tani S, Nakashima H and Sakagami H: Biological activity of 3-formylchromones and related compounds. In Vivo 21: 829-834, 2007.
18. Sakagami H, Kawase M, Wakabayashi H and Kurihara T: Factors that affect the type of cell death induced by chemicals. Autophagy 3: 493-495, 2007.
19. Okamura M, Kobayashi M, Suzuki F, Shimada J and Sakagami H: Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line. Anticancer Res 27 (6), 3331-3338, 2007.
20. Takekawa F, Nagumo T, Shintani S, Hashimoto K, Kikuchi H, Katayama T, Ishihara M, Amano O, Kawase M and Sakagami H: Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines. Anticancer Res 27: 4065-4070, 2007.
21. Suzuki F, Hashimoto K, Ishihara M, Westman G, Samuelsson K, Kawase M, Motohashi N and Sakagami H: Tumor-specificity and type of cell death induced by phenoxazines. Anticancer Res 27: 4233-4238, 2007.
22. Sakagami H, Hashimoto K, Suzuki F, Ishihara M, Kikuchi H, Katayama T and Satoh K: Tumor-specificity and type of cell death induced by vitamin K2 derivatives and prenylalcohols. Anticancer Res 28: 151-158, 2008
23. Liu Y, Sakagami H, Hashimoto K, Kikuchi H, Amano O, Ishihara M, Kanda Y, Kunii S, Kochi M, Zhang W and Yu G: Tumor-specific cytotoxicity and type of cell death induced by β-cyclodextrin benzaldehyde inclusion compound. Anticancer Res 28: 229-236, 2008.
24. Okamura M, Shimada J and Sakagami H: Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines. Anticancer Res 28: 253-260, 2008.
25. Pati HN, Das U, Quail JW, Kawase M, Sakagami H and Dimmock JR: Cytotoxic 3,5-bis(arylidene)-4-piperidones and N-acetylanalogs displaying selective toxicity for malignant cells. Eur J Med Chem: 43: 1-7, 2008.
26. Klionsky D, Sakagami et al.: Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryots. Autophagy 4 (2): 151-175, 2008.
27. Perjesi P, De Clercq E, Balzarini J, Kawase M, Sakagami H, Stables JP, Lorand T, Rozmer Z and Dimmock JR: Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells. Eup J Med Chem 43: 839-845, 2008.
28. Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N and Sakagami H: Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines. Anticancer Res 28: 1069-1078, 2008.
29. Pati HN, Das U, Kawase M, Sakagami H, Balzarini J, De Clercq E and Dimmock JR: 1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: a quest for selective cytotoxicity for malignant cells. Bioorg Med Chem 16: 5747-5753, 2008
30. Hashimoto K and Sakagami H: Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line. 　　 Anticancer Res 28: 1713-1718, 2008.
31. Sakagami H, Kobayashi M, Ishihara M, Kikuchi H, Nakamura Y, Kawase M and Motohashi N: Tumor-specificity and type of cell death induced by heterocycles. Topics in Heterocyclic Chemistry (ed., Noboru Motohash), Springer of Germany 15: 173-199, 2008 Springer-Verlag Berlin Heidelberg.
32. Liu Y, Sakagami H, Amano O, Kikuchi H, Nakamura Y, Ishihara M, Kanda Y, Kunii S, Zhang W and Yu G: Tumor-specific cytotoxicity and type of cell death induced by peplomycin in oral squamous cell carcinoma cell lines. Anticancer Res 28: 2197-2204, 2008.
33. Kishino K, Hashimoto K, Amano O, Kochi M and Sakagami H: Tumor-specificic cytotoxicity and type of cell death induced by sodium 5,6-benzylidene-L-ascorbate. Anticancer Res 28: 2577-2584, 2008.
34. Pati HN, Das U, Bandy B, Das S, De Clercq E, Balzirini J, Kawase M, Sakagami H, Quail JW, Stables JP and Dimmock JR: The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1]octan- 3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones. Eur J Med Chem 44: 54-62, 2009.
35. Ideo A, Hashimoto K, Shimada J, Kawase M and Sakagami H: Type of cell death induced by a-trifluoromethyl acyloins in oral squamous cell carcinoma. Anticancer Res 29: 175-182, 2009.
36. Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohiashi N, Sakagami H, Yamamoto K and Tanaka A: Tumor-specific cytotoxicity and type of cell death induced by naphtha[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure. Anticancer Res 29: 455-464, 2009.
37. Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T and Wakabayashi H: Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives. Anticancer Res 29: 1123-1130, 2009.
38. Hashimmoto K, Suzuki F and Sakagami H: Declined asparagine synthetase mRNA expression and enhanced sensitivity to asparaginase in HL-60 cells committed to monocytic differentiation. Anticancer Res 29: 1303-1308, 2009.
39. Kawase M, Sakagami H and Motohashi N: The chemistry of bioactive mesoionic heterocycles. Top Heterocycl Chem (2009)16: 135-152, (ed., Noboru Motohash), Springer-Verlag Berlin Heiderberg.
40. Mimaki Y, Watanabe K, Matsuo Y and Sakagami H: Triterpene glycosides from the tibers of Anemone coronaria. Chem Pharm Bull 57: 724-729, 2009.
41. Chu Q, Hashimoto K, Satoh K, Wang Q and Sakagami H: Effect of three herbal extracts on NO and PGE2 production by activated mouse macrophage-like cells. In VIVO 23: 537-544, 2009.
42. Das U, Pati HN, Panda AK, De Clercq E, Balzarini J, Molnár J, Baráth Z, Ocsovszki I, Kawase M, Zhou L, Sakagami H and Dimmock JR: 2-(3-Aryl-2-propenoyl)-3-methylquinoxaline- 1,4-dioxides: A novel cluster of tumor-specific cytotoxins which reverse multidrug resistance. Bioorg Med Chem 17: 3909-3915, 2009.
43. Hatano H, Takekawa H, Hashimoto K, Ishihara M, Kawase M, Chu Q, Wang QT and Sakagami H: Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines Anticancer Res 29: 3079-3086, 2009
44. Chu Q, Kobayashi M, Hashimoto K, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Wang Q and Sakagami H: Antitumor potential of three herbal extracts against human oral squamous cell lines. Anticancer Res 29: 3211-3219, 2009.
45. Yokosuka A, Sano T, Hashimoto K, Sakagami H and Mimaki Y: Steroidal glycosides from Furcraea foetida and their cytotoxic activity. Chem Pharm Bull 57: 1161-1166, 2009.
46. Jitsuno M, Yokosuka A, Sakagami H and Mimaki Y: Chemical constituents of the Bulbs of Habranthus brachyandrus and their cytotoxic activities. Chem Pharm Bull 57: 1153-1157, 2009.
47. Yokosuka A, Sano T, Hashimoto K, Sakagami H and Mimaki Y: Triterpene glycosides from the whole plant of Anemone hupehensis var. japonica and their cytotoxic activity. Chem Pharm Bull 57: 1425-1430, 2009.
48. Chu Q, Amano O, Kanda Y, Kunii S, Wang Q and Sakagami H: Tumor-specific cytotoxicity and type of cell death induced by gefitinib in oral squamous cell carcinoma cell lines. Anticancer Res 29: 5023-5031, 2009.
49. Das U, Sakagami H, Chu Q, Wang Q, Kawase M, Selvakumar P, Sharma RK and Dimmock JR: 3,5-bis(Benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: A lead tumour-specific cytotoxin which induces apoptosis and autophagy". Medicinal Chemistry Letters 20: 912-917, 2010.
50. Kaneko T, Chiba H, Horie N, Kato T, Kobayashi M, Hashimoto K, Kusama K and Sakagami H: Inhibition of prostaglandin E2 production by flavone and its related compounds. In vivo 24: 55-58, 2010.
51. Kuroda M, Uchida S, Sakagami H and Mimaki Y: Amurenosides A-K, 11 new pregnane glycosides from the roots of Adonis amurensis. Steroids: 75: 83-94, 2010.
52. Das U, Doroudi A, Gul HI, Pati HN, Kawase M, Sakagami H, Chu Q, Stables JP and Dimmock JR: Cytotoxic 2-benzylidene-6-(nitrobenzylidene)cyclohexanones which display substantially greater toxicity for neoplasms than non-malignant cells. Bioorg Med Chem 18: 2219-2224, 2010
53. Orabi MA, Taniguchi S, Yoshimura M, Yoshida T, Kishino K, Sakagami H and Hatano T: Hydrolyzable tannins of tamaricaceous plants III. New Hellinoyl- and macrocyclic-type ellagitannins from Tamarix nilotica. J Nat Prod 73: 870-879, 2010.
54. Cheung FWK, Che CT, Sakagami H, Kochi M and Liu WK: Sodium 5,6-benzylidene-L- ascorbate induces oxidative stress, autophagy and growth arrest in human colon cancer HT-29 cells. Journal of Cellular Biochemistry 111: 412-424, 2010.
55. Pati HN, Das U, Sakagami H, Kawase M, Chu Q,Wang Q, Stables JP and Dimmock JR: 1,3-Diaryl-2-propenones and 2-benzylidene-1,3-indandiones: A quest for compounds displaying greater toxicity to neoplasms than normal cells. Arch Pharm Chem Life Sci 9:535-541, 2010.
56. Mimaki Y, Matsuo Y, Watanabe K and Sakagami H: Furostanol glycosides from the rhizomes of Helleborus orientalis. J Nat Med 64(4):452-459, 2010.
57. Kato T, Horie N, Hashimoto K, Satoh K, Shimoyama T, Kakeno T, Kusama K and Sakagami H: Effect of itraconazoles on the production of pro-inflammatory substances in mouse macrophage-like cells. In Vivo 24: 709-714, 2010.
58. Das S, Das U, Sakagami H, Hashimoto K, Kawase M, Gorecki DK and Dimmock JR: Sequential cytotoxicity: a theory examined using a series of 3,5-bis(benzylidene)-1- diethylphosphono-4-oxopiperidines and related phosphonic acids. Bioorg Med Chem Lett 20:6464-6468, 2010.
59. Ariyoshi-Kishino K, Hashimoto, K, Amano O, Kochi M and Sakagami H: Tumor-specific cytotoxicity and type of cell death induced by benzaldehyde. Anticancer Res 30: 5069-5076, 2010.
60. Jitsuno M, Yokosuka A, Hashimoto K, Amano O, Sakagami H and Mimaki Y: Chemical constituents of Lycoris albiflora and their cytotoxic activities. Natural Product Communications 6, 187-192, 2011
61. Horii H, Ueda J, Tamura M, Sakagami H, Tomomura M, Tomomura A and Shirataki Y: Search for new biological activity of Rhinacanthus nasutus extracts. In Vivo 25: 367-374, 2011.
62. Masuda Y, Ueda J, Tamura M, Sakagami H, Tomomura M, Tomomura A and Shirataki Y: Diverse biological activity of Odontioda Marie Noel ‘Velano’ extracts. In Vivo 25: 375-380, 2011.
63. Masuda Y, Ueda J, Tamura M, Sakagami H, Tomomura M, Tomomura A and Shirataki Y: Diverse biological activity of Odontoglossum Harvengtens ‘Tutu’ bulb extracts, In Vivo 25: 381-386, 2011.
64. Das U, Pati H, Sakagami H, Hashimoto K, Kawase M, Balzarini J, De Clercq E, Stables J and Dimmock: 3,5-bis(Benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]-piperidin-4-ones :A novel cluster of potent tumour-selective cytotoxins. J Med Chem, in press, 2011.

1. Kurihara T, Noguchi M, Noguchi T, Wakabayashi H, Motohashi N and Sakagami H: Relationship between electronic structure and cytotoxic activity of azulenes. In vivo 20: 385-390, 2006.
2. Kurihara T, Mine H, Satoh Y, Wakabayashi H, Motohashi N and Sakagami H: Relationship between electronic structure and cytotoxic activity of tropolones. In vivo 20: 391-396, 2006.
3. Ishihara M, Yokote Y and Sakagami H: Quantitative structure-cytotoxicity relationship analysis of coumarin and its derivatives by semiempirical molecular-orbital method. Anticancer Res 26: 2883-2886, 2006.
4. Kurihara T, Satoh R, Miyagawa T, Wakabayashi H, Motohashi N and Sakagami H: Relationship between electronic structure and cytotoxic activity of azulenequinones and trihaloacetylazulenes. In vivo 21: 715-720, 2007.
5. Ishihara M, Kawase M and Sakagami H: Quantitative structure-activity relationship analysis of 4-trifluoromethylimidazole derivatives with the concept of absolute hardness. Anticancer Res 27: 4047-4052, 2007.
6. Ishihara M, Kawase M, Westman G, Samuelson K, Motohashi N and Sakagami H: Quantitative Structure-cytotoxicity relationship analysis of phenoxazine derivatives by semiempirical molecular-orbital method. Anticancer Re 27: 4053-4058, 2007.
7. Ishihara M and Sakagami H: QSAR of molecular structure and cytotoxic activity of vitamin K2 derivatives with concept of absolute hardness. Anticancer Res 27: 4059-4064, 2007.
8. Ishihara M and Sakagami H: Quantitative structure-cytotoxicity relationship analysis of 3-formylchromone derivatives by semiempirical molecular-orbital method with concept of absolute hardness. Anticancer Res 28: 277-282, 2008.
9. Ishihara M, Kawase M and Sakagami H: Quantitative structure-cytotoxicity relationship analysis of 5-trifluoromethyloxazole derivatives by semiempirical molecular-orbital method with concept of absolute hardness. Anticancer Res 28: 997-1004, 2008.
10. Kurihara T, Shinohara K, Inabe M, Wakabayashi H, Motohashi N, Sakagami H and Molnar J: Theoretical studies on phenothiazines, benzo[a]phenothiazines, and benz[c]acridines. Topics in Heterocyclic Chemistry (ed., Noboru Motohash), Springer of Germany 15: 253-279, Springer-Verlag Berlin Heidelberg.
11. Ishihara M, Sakagami H, Kawase M and Motohashi N: Quantitative Structure-Cytotoxicity Relationship of bioactive heterocycles by semi-empirical molecular orbital method with concept of absolute hardness. Top Heterocycl Chem (2009)16: 93-133, (ed., Noboru Motohash), Springer-Verlag Berlin Heiderberg.
12. Ishihara M, Hatano H, Kawase M and Sakagami H: Estimation of relationship between the structure of 1,2,3,4-tetrahydroisoquinolin derivatives determined by a semiempirical molecular-orbital method and their cytotoxicity. Anticancer Res 29: 2265-2272, 2009.
13. Ishihara M, Hatano H, Takekawa F, Kawase M and Sakagami H: Estimation of relationship between descriptors and cytotoxicity of newly synthesized 1,2,3,4-tetrahydroisoquinoline derivatives. Anticancer Res 29: 4077-4082, 2009.
14. Takekawa F, Sakagami H and Ishihara M: Estimation of relationship between structure of newly synthesized dihydroimidazoles determined by a semiempirical molecular-orbital method and their cytotoxicity. Anticancer Res 29: 5019-5022, 2009.
15. Ishihara M, Wakabayashi H, Motohashi N and Sakagami H: Quantitative Structure– cytotoxicity Relationship of newly synthesized tropolones determined by a semiempirical molecular-orbital method (PM5) Anticancer Res 30: 129-133, 2010.
16. Ishihara M, Wakabayashi H, Motohashi N and Sakagami H: Estimation of relationship between the structure of trihaloacetylazulene derivatives determined by a semiempirical molecular-orbital method (PM5) and their cytotoxicity. Anticancer Res 30: 837-842, 2010.
17. Ishihara M, Wakabayashi H, Motohashi N and Sakagami H: Quantitative Structure– Cytotoxicity Relationship of Newly Synthesized Trihaloacetylazulenes Determined by a Semiempirical Molecular-Orbital Method (PM5). Anticaner Res 31: 515-520, 2011.

（１０）シグナル伝達

1. Hasegawa H, Kido S, Tomomura M, Fujimoto K, Ohi M, Kiyomura M, Kanagae H, Inaba A, Sakagami H and Tomomura A: Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity. J Biol Chem 285 (33): 25448-25457, 2010.
2. Tomomura M, Fujii T, Sakagami H and Tomomura A: Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice. In Vivo 25,157-164, 2011.

友村プロジェクト

1. Tomomura M, Morita N, Yoshikawa F, Konishi A, Akiyama H, Furuichi T and Kamiguchi H: Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. 　 Neuroscience 148: 510-521, 2007.
2. Tsutumi, K, Tomomura M , Furuichi T and Hisanaga S: Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src. Genes cells 13: 949-964, 2008.
3. 長谷川紘也、鐘ヶ江晴秀、稲葉明美、友村美根子、友村明人: 血清カルシウム降下因子（カルデクリン） よる滑膜線維芽細胞のRANKL発現の抑制, 明海歯科医学 39: ４２－51, 2010.
4. Tsutsumi K, Takano T, Endo R, Fukuda M, Ohshima T, Tomomura M and Hisanaga: Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation. PLoS One 5: e10260, 2010.
5. Hasegawa H, Kido S, Tomomura M, Fujimoto K, Ohi M, Kiyomura M, Kanegae H, Inaba A, Sakagami H & Tomomura A: Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity: J Biol Chem 285: 25448-25457, 2010.
6. Takano T, Tsutsumi K, Saito T, Asada A, Tomomura M, Fukuda M, Hisanaga S: AATYK1A phosphorylation by Cdk5 regulates the recycling endosome pathway. Genes cells 13: 949-964. 2010.
7. Tomomura M, Fujii T, Sakagami H and Tomomura A: Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice. In Vivo 25: 157-164, 2011.
8. Horii H, Ueda J, Tamura M, Sakagami H, Tomomura M, Tomomura A and Shirataki Y: Search for new biological activity of Rhinacanthus nasutus extracts. In Vivo 25: 367-374, 2011.
9. Masuda Y, Ueda J, Tamura M, Sakagami H, Tomomura M, Tomomura A and Shirataki Y: Diverse biological activity of Odontioda Marie Noel ‘Velano’ extracts. In Vivo 25: 375-380, 2011.
10. Masuda Y, Ueda J, Tamura M, Sakagami H, Tomomura M, Tomomura A and Shirataki Y: Diverse biological activity of Odontoglossum Harvengtens ‘Tutu’ bulb extracts, In Vivo 25: 381-386, 2011.
11. Furuichi T, Shiraishi-Yamaguchi Y,Sato A, Sadakata T, Huang J-H, Shinoda Y, Hayashi K, Mishima Y, Tomomura M and Yoshikawa F: Systematizing and cloning of genes involved in the cerebellar cortex circuit development. Neurochem Res: in press, 2011
12. Kushida T, Makino T, Tomomura M, Tomomura A and Sakagami H: Enhancement of dectin-2 gene expression by lignin-carbohydrate complex from Lendinus edodes extract (LEM) in mouse macrophage-like cell line. Anticancer Res 31: in press, 2011.